These lesions are often lytic, but cases of diffuse osteosclerosis, mixed sclerotic and lytic pattern, and osteoporosis have also been reported [9]. In this review, we focus on the disease-specific gene mutations in MLN discovered by recent massive sequencing technologies. A subset of patients can have an aggressive clinical course. Interferon-alpha Interferon-alpha is an immune system hormone that is very helpful to a relatively small number of patients, and somewhat helpful to most patients. Targeted therapy is a treatment that uses drugs or other substances to identify and attack specific cancer cells without harming normal cells. The drug cladribine is the initial treatment for most people who have hairy cell leukemia. This case highlights that careful hematopathological assessment and clinical correlation is required for accurate diagnosis of unusual cases of hairy cell leukemia.
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Unusual presentation of hairy cell leukemia as isolated bone lesions

There is also a higher risk of developing an autoimmune disease. Therefore, we performed whole exome sequencing to explore the mutational landscape of purine analog refractory HCL. Easy bruising or bleeding. Patients with the BRAF VE mutation had a significantly higher frequency of neutropenia, thrombocytopenia, and elevated soluble interleukin-2 receptor and common B-cell surface markers than patients without the mutation. In hairy cell leukemia, the "hairy cells" malignant B lymphocytes accumulate in the bone marrow, interfering with the production of normal white blood cells , red blood cells , and platelets.
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Unusual presentation of hairy cell leukemia as isolated bone lesions

Interferon alfa Intron A, Wellferon is a type of biological therapy that is commonly used to treat progressive, relapsed or refractory hairy cell leukemia. Figure 4 Skull lesion showed diffuse expression of Cyclin D1. Your healthcare team will work with you to decide on follow-up care to meet your needs. The leukemia cells can build up in the blood and bone marrow so there is less room for healthy white blood cells, red blood cells, and platelets. Treatment of hairy cell leukemia may include the following:. T lymphocytes that help B lymphocytes make antibodies to help fight infection.
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Hairy cell leukemia and its treatments can cause certain problems, including infection, bleeding and low blood cell counts. Check with your doctor if you have any of the following:. Rare cases of neurological and skeletal bone involvement have been reported in the literature []. A monoclonal antibody called rituximab may be used for certain patients with hairy cell leukemia. Talking about Your Advanced Cancer.
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Hairy cell lymphoma

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